900000000000508004: Great Britain English language reference set (foundation metadata concept)

SNOMED CT Concept\SNOMED CT Model Component\Foundation metadata concept (foundation metadata concept)\Reference set\Language type reference set (foundation metadata concept)\English [International Organization for Standardization 639-1 code en] language reference set (foundation metadata concept)\GB English

Status: current, Not sufficiently defined by necessary conditions definition status (core metadata concept). Date: 31-Jan 2002. Module: SNOMED CT model component module (core metadata concept)

Descriptions:

Expanded Value Set

Outbound Relationships	Type	Target	Active	Characteristic	Refinability	Group	Values
GB English	Is a	English [International Organization for Standardization 639-1 code en] language reference set (foundation metadata concept)	true	Inferred relationship	Some

Members	acceptabilityId
A method of administration of a dose form by blowing it into a body cavity.	Preferred (foundation metadata concept)
A method of administration of a dose form by chewing or biting prior to allowing to pass down the throat.	Preferred (foundation metadata concept)
A method of administration of a dose form by introducing it into the body, usually after puncturing the skin; typically used for small volumes of liquid administered over a brief duration.	Preferred (foundation metadata concept)
A method of administration of a dose form by placing it in the mouth and allowing it to dissipate; the product is usually then swallowed.	Preferred (foundation metadata concept)
A method of administration of a dose form by placing or spreading on a body surface.	Preferred (foundation metadata concept)
A method of administration of a dose form by taking into the mouth and allowing to pass down the throat.	Preferred (foundation metadata concept)
A method of administration of a dose form by using the tongue and muscles of the mouth to dissolve it.	Preferred (foundation metadata concept)
A method of administration of a dose form gradually, possibly drop by drop.	Preferred (foundation metadata concept)
A method of administration of a dose form into the respiratory tract by breathing, sucking or sniffing.	Preferred (foundation metadata concept)
A method of administration of a dose form through a dialysis system.	Preferred (foundation metadata concept)
A method of administration of a liquid dose form by flushing it through or flow over a body area.	Preferred (foundation metadata concept)
A method of administration of a liquid dose form by flushing it through, flowing it over, or cleansing a body area.	Preferred (foundation metadata concept)
A method of administration of a liquid dose form by rinsing the oropharyngeal area with the head held back and breath expired to produce a bubbling.	Preferred (foundation metadata concept)
A method of administration of a liquid dose form usually slowly and over a prolonged period of time and typically in larger volumes by introducing it into the circulatory system or into a body cavity.	Preferred (foundation metadata concept)
A method of counting entities performed in a manual way. This method is intended to be used for counting various entities including cells, cell particles, organisms, and spermatozoa.	Preferred (foundation metadata concept)
A method of counting entities performed in an automated way. This method is intended to be used for counting various entities including cells, cell particles, organisms, and spermatozoa.	Preferred (foundation metadata concept)
A method used to accurately capture and study eye movements. It works by using specialised cameras to track the position and motion of the eyes, recording these movements for detailed analysis.	Preferred (foundation metadata concept)
A microdeletion occurring on the short (p) arm of chromosome 16 at a location designated p12.2. Common characteristics of this disease include developmental delay, delayed speech, intellectual disability, hypotonia, short stature, microcephaly, cardiac malformations, recurrent epilepsy, psychiatric and behavioural problems. Manifestations vary even among affected members of the same family. Inherited in an autosomal dominant pattern with incomplete penetrance, in almost all known cases the chromosomal change has been inherited from a parent	Preferred (foundation metadata concept)
A microorganism is categorised as "Resistant" when there is a high likelihood of therapeutic failure even when there is increased exposure.	Preferred (foundation metadata concept)
A microorganism is categorised as "Susceptible, Increased exposure" when there is a high likelihood of therapeutic success because exposure to the agent is increased by adjusting the dosing regimen or by its concentration at the site of infection.	Preferred (foundation metadata concept)
A microorganism is categorised as "Susceptible, standard dosing regimen" when there is a high likelihood of therapeutic success using a standard dosing regimen of the agent.	Preferred (foundation metadata concept)
A microsatellite is defined as the presence of a microscopic cutaneous, discontinuous metastasis found adjacent or deep to a primary melanoma.	Preferred (foundation metadata concept)
A mid-life onset distal myopathy with characteristics of tibialis anterior weakness and progressive respiratory muscle involvement present from the onset of the disease. It has been described in three generations of a family (11 patients). Transmission is autosomal dominant and an anticipation phenomenon is suspected. No genes have yet been identified.	Preferred (foundation metadata concept)
A mid-to-late diastolic murmur heard best at the cardiac apex, heard in cases of aortic insufficiency.	Preferred (foundation metadata concept)
A mild form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy, characterised by distal legs sensory loss and weakness that can be asymmetric. Tendon reflexes are reduced in the knees and absent in ankles. Progression is slow.	Preferred (foundation metadata concept)
A mild form of familial adenomatous polyposis characterised by the presence of fewer than 100 adenomatous colonic polyps, a more proximal colonic location, a delayed age of colorectal cancer onset and a more limited expression of the extracolonic features.	Preferred (foundation metadata concept)
A mild form of familial primary hypomagnesaemia (FPH), characterised by extreme weakness, tetany and convulsions. Secondary disturbances in calcium excretion are observed.	Preferred (foundation metadata concept)
A mild form of haemophilia A characterised by a small deficiency of factor VIII (biological activity between 5 and 40 IU/dL) leading to abnormal bleeding as a result of minor injuries or following surgery or tooth extraction. Spontaneous haemorrhages do not occur. Patients may be also labelled as having mild haemophilia A if they have a FVIII >40 IU/dL and a DNA change in the F8 gene and one of the following: (i) a family member with the same DNA change and FVIII of <40 IU/dL, and the DNA change is found in <1% of the population; and (ii) the international databases list the DNA change as being associated with haemophilia A and <40 IU/dL FVIII. The condition may affect males and female carriers of disease-causing mutations.	Preferred (foundation metadata concept)
A mild subtype of autosomal recessive limb-girdle muscular dystrophy characterised by a variable onset (ranging from infancy to adolescence) of progressive proximal upper and lower limb muscle weakness and atrophy. Mild scapular winging, calf hypertrophy, and lack of respiratory and cardiac involvement are also observed.	Preferred (foundation metadata concept)
A mild subtype of citrin deficiency characterised clinically by low birth weight, failure to thrive, transient intrahepatic cholestasis, multiple aminoacidaemia, galactosaemia, hypoproteinaemia, hepatomegaly, decreased coagulation factors, haemolytic anaemia, variable but mostly mild liver dysfunction, and hypoglycaemia.	Preferred (foundation metadata concept)
A minimally invasive surgical procedure which involves the use of specialised endoscopic instruments and equipment to access and treat the spine through two small incisions. The term "unilateral" refers to the fact that the procedure is performed on one side of the spine.	Preferred (foundation metadata concept)
A mitochondrial disorder of long chain fatty acid oxidation characterised in most patients by onset in infancy or early childhood with hypoketotic hypoglycaemia, metabolic acidosis, liver disease, hypotonia and frequently cardiac involvement with arrhythmias and/or cardiomyopathy. Caused by the isolated deficiency of long chain 3-hydroxyacyl-CoA dehydrogenase, an enzyme of the mitochondrial trifunctional protein complex (TFP). TFP is a heterooctamer of 4 alpha and 4 beta subunits. The disease is due to mutations in the HADHA gene (2p23) that encodes for the alpha subunit of TFP. Mitochondrial trifunctional protein deficiency is clinically indistinguishable from this disease.	Preferred (foundation metadata concept)
A mitochondrial oxidative phosphorylation disorder characterised by hypertrophic and dilated cardiomyopathy, failure to thrive, myopathy with generalised hypotonia and increased creatine kinase, developmental delay and/or regression with cerebral atrophy on brain MRI, renal manifestations including chronic renal failure, renal tubular acidosis and lactic acidosis. Additional clinical features include seizures and respiratory failure.	Preferred (foundation metadata concept)
A mixed epithelial neoplasm that is composed of both neuroendocrine and non neuroendocrine components with variable proportions for each component.	Preferred (foundation metadata concept)
A mixture used for intravenous nutrition, which may include protein, carbohydrate, fat, minerals and electrolytes, vitamins and other trace elements for patients who cannot eat or absorb enough food through tube feeding formula or by mouth to maintain good nutrition status.	Preferred (foundation metadata concept)
A motion or state where one end of a part is twisted about a longitudinal axis while the opposite end is held fast or turned in the opposite direction.	Preferred (foundation metadata concept)
A multimodal process of optimising functional status prior to surgery with the aim of maintaining a normal level of functioning after surgery in order to improve postoperative outcome.	Preferred (foundation metadata concept)
A multiple congenital anomalies syndrome characterised by wormian bones, dextrocardia and short stature due to a growth hormone deficiency. Additional manifestations that have been reported include brachycamptodactyly, kidney hypoplasia, bilateral cryptorchidism, midshaft hypospadias, imperforate anus/anorectal agenesis, body asymmetry, mild developmental delay, hemimegalencephaly and facial dysmorphism (hypotelorism, downslanting palpebral fissures, low-set and posteriorly angulated ears, depressed nasal bridge, and microstomia).	Preferred (foundation metadata concept)
A multiple congenital anomalies/dysmorphic - intellectual disability syndrome characterised by feeding problems, growth retardation, microcephaly, developmental delay, digital and vertebral anomalies, joint laxity/dislocation, cardiac and renal defects, and dysmorphic facial features (including plagiocephaly, prominent forehead, bitemporal narrowing, bilateral coloboma, epicanthal folds, malformations of the outer and middle ear, wide nasal bridge, anteverted nares, prominent and bulbous nose tip, long philtrum, thin lips, high and narrow palate, micrognathia with prognathism/retrognathism, full cheeks, and short, broad neck). Additional variable manifestations include obstructive apnoeas, recurrent pneumonia, and seizures.	Preferred (foundation metadata concept)
A multiple congenital anomaly disorder characterised by anonychia congenita totalis and microcephaly, and normal intelligence along with some minor anomalies including single transverse palmar creases, fifth-finger clinodactyly and widely spaced teeth.	Preferred (foundation metadata concept)
A multiple congenital developmental anomalies syndrome characterised by arachnodactyly of fingers and toes associated with craniofacial dysmorphism (including abnormal cranial ossification, frontal bossing, flat calvaria, shallow deformed orbits resulting in exophthalmos, midface hypoplasia and micrognathia), feeding difficulties in infancy, infantile muscular hypotonia, and developmental delay leading to intellectual disability.	Preferred (foundation metadata concept)
A natural tooth that will be used as a retainer for a fixed prosthesis. A tooth that is well aligned with no previous restorations or other damage that would compromise its strength.	Preferred (foundation metadata concept)
A natural tooth that will be used as a retainer for a fixed prosthesis. A tooth that is well aligned, but has had previous restorations or other damage in 1 or 2 sextants of the tooth that reduce its potential strength.	Preferred (foundation metadata concept)
A natural tooth that will be used as a retainer for a fixed prosthesis. A tooth that is well aligned, but has had previous restorations or other damage in 3 sextants of the tooth that reduce its potential strength.	Preferred (foundation metadata concept)
A natural tooth that will be used as a retainer for a fixed prosthesis. A tooth that is well aligned, but has had previous restorations or other damage to 4 or more sextants of the tooth that reduce its potential strength.	Preferred (foundation metadata concept)
A natural tooth that will be used as a retainer for a fixed prosthesis. A tooth that may have had limited previous treatment or is not perfectly aligned.	Preferred (foundation metadata concept)
A neoplasm considered precancerous and/or with high potential to become malignant. In solid organ neoplasms, the neoplasm has not broken through a basement membrane.	Preferred (foundation metadata concept)
A neoplasm that occurs in the central portion of the breast, extending 1 cm around the areola, but does not involve the nipple or areola.	Preferred (foundation metadata concept)
A neoplasm that remains in the location of origin and does not pass through the basement membrane of the tissue of origin.	Preferred (foundation metadata concept)
A neural tube defect with characteristics of improper closure of the spinal column during embryonal development. In the case of spina bifida occulta the site of the lesion is not exposed, there is a midline defect of the vertebral bodies without protrusion of the spinal cord or meninges.	Preferred (foundation metadata concept)
A neurodegenerative disease with characteristics of progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. Associated with mutations in the superoxide dismutase-1 gene (SOD1) on chromosome 21q22.	Preferred (foundation metadata concept)
A neurodegenerative disease with characteristics of progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. Associated with the ALS3 gene on the cytogenetic location 18q21.	Preferred (foundation metadata concept)
A neurodegenerative disease with characteristics of progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. Caused by heterozygous mutation in the FUS gene on chromosome 16p11.	Preferred (foundation metadata concept)
A neurodegenerative disease with characteristics of progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. Caused by heterozygous mutation in the VAPB gene on chromosome 20q13.	Preferred (foundation metadata concept)
A neurodegenerative disease with characteristics of progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. Caused by heterozygous mutation in the angiogenin gene (ANG) on chromosome 14q11.	Preferred (foundation metadata concept)
A neurodegenerative disease with characteristics of progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. Cytogenetic location is 20p13.	Preferred (foundation metadata concept)
A neurodegenerative disease with characteristics of progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord. There is evidence this disease is caused by heterozygous mutation in the TARDBP gene that encodes the TDP43 protein on chromosome 1p36.	Preferred (foundation metadata concept)
A neurological disorder with characteristics of moderate to severe developmental delay and intellectual disability and mild dysmorphic features. Early symptoms include hypotonia, delayed development of motor skills, speech delay, hypertelorism, broad nasal bridge, and fingers with tapered ends. Other features include microcephaly, seizures, recurrent ear infections, strabismus, amblyopia and hyperopia. Behavioural problems such as hyperactivity, attention deficit disorder, aggression, anxiety and autism spectrum occur in some cases. Caused by mutations in the HIVEP2 gene leading to a shortage of functional HIVEP2 protein. Inherited in an autosomal dominant pattern however most cases of this condition result from de novo mutations in the gene.	Preferred (foundation metadata concept)
A neurological disorder with characteristics of moderate to severe developmental delay and intellectual disability. Additional manifestations may include hypotonia, delayed development of motor skills, delayed speech development, recurrent seizures, autism spectrum disorder, macrocephaly and unusual facial features including frontal bossing, hypertelorism and downslanting palpebral fissures. Caused by mutations in the PPP2R5D gene, which provides instructions for making B56-delta resulting in the production of an altered B56 protein. Inherited in an autosomal dominant pattern however most cases of this condition result from de novo gene mutation.	Preferred (foundation metadata concept)
A neurological disorder with characteristics of moderate to severe intellectual disability that is evident in early childhood. Early manifestations include delayed development of speech and motor skills, hypotonia, developmental regression, recurrent epilepsy, hyperactivity and autism spectrum disorder. Caused by mutations in the SYNGAP1 gene preventing the production of functional SynGAP protein from one copy of the gene which results in reduced protein activity in cells. May be inherited in an autosomal dominant manner or as a new mutation in the gene.	Preferred (foundation metadata concept)
A neurosurgical procedure where a patient is awake and alert during a craniotomy, allowing the surgeon to monitor brain function in real-time while removing a tumour or lesion.	Preferred (foundation metadata concept)
A new leucoencephalopathy, the CACH syndrome (Childhood Ataxia with Central nervous system Hypomyelination) or VWM (Vanishing White Matter) was identified on clinical and MRI criteria. Classically, this disease is characterised by onset between 2 and 5 years of age, with a cerebello-spastic syndrome exacerbated by episodes of fever or head trauma leading to death after 5 to 10 years of disease evolution, a diffuse involvement of the white matter on cerebral MRI with a CSF-like signal intensity (cavitation), a recessive autosomal mode of inheritance, neuropathologic findings consistent with a cavitating orthochromatic leucodystrophy with increased number of oligodendrocytes with sometimes foamy aspect.	Preferred (foundation metadata concept)
A new narcotic or psychotropic drug that is not controlled by the United Nations drug conventions, but which may pose a public health threat comparable to that posed by substances listed in these conventions.	Preferred (foundation metadata concept)
A new narcotic or psychotropic substance that is not controlled by the United Nations drug conventions, but which may pose a public health threat comparable to that posed by substances listed in these conventions.	Preferred (foundation metadata concept)
A newly described variant of Ehlers-Danlos syndrome (EDS). Affected patients exhibit features consistent with EDS, including joint hypermobility, skin fragility and aortic dilatation. They also have periventricular heterotopia, which has characteristics of focal epilepsy usually beginning in the second decade of life. Intelligence is generally normal. Some patients also have cardiac anomalies such as patent ductus arteriosus, bicuspid aortic valves, or aneurysmal dilatation of the sinus of Valsalva. Caused by mutations in the filamin A gene (FLNA) located at locus Xq28 on the long arm of chromosome X. This suggests a novel cause of EDS. The disease is transmitted as an X-linked dominant trait.	Preferred (foundation metadata concept)
A non-medical person who provides support, assistance and companionship in the end of life process.	Preferred (foundation metadata concept)
A non-medical person who stays with and assists a woman before, during, or after childbirth.	Preferred (foundation metadata concept)
A non-neoplastic lesion that occurs in response to injury, including previous surgery.	Preferred (foundation metadata concept)
A non-sterile electrical conductor designed to be applied to an adult patient for automatic or manual defibrillation, external pacing, cardioversion, and electrocardiographic monitoring through transmission of cardiac bioelectric signals (typically from the thoracic surface) to devices that record/process the signals and potentially return electrical impulses [e.g. electrocardiograph, electrocardiographic monitor(s), defibrillator]. It is a disk-like electrode that is affixed to the skin with a special adhesive and a conductive gel (pre-gelled). It may be made of x-ray translucent materials and may include permanently attached lead wires.	Preferred (foundation metadata concept)
A non-sterile, urine drainage device for men that typically consists of a flexible tube attached to a condom-like sheath. The sheath is fitted over the penis to channel urine, via the tube, into a collection bag.	Preferred (foundation metadata concept)
A nutrition counselling technique that involves keeping a detailed record of behaviours that influence diet and/or weight.	Preferred (foundation metadata concept)
A nutritional product with modified amino acid composition.	Preferred (foundation metadata concept)
A painful low back condition characterised by hypertonicity of psoas musculature.	Preferred (foundation metadata concept)
A painful restriction of joint motion caused by excessive scarring following injury or operative procedure.	Preferred (foundation metadata concept)
A palpable change in the tissues of the body away from their normal state.	Preferred (foundation metadata concept)
A parameter is an entity whose value is determined by decision of an agent as opposed being observed in reality. Examples of parameters are goals or targets, equipment settings, and treatment parameters.	Preferred (foundation metadata concept)
A parasitic disease caused by Cyclospora cayetanensis, a recently discovered coccidia that was initially described in Peru and then in most intertropical zones. Infection occurs through ingestion of contaminated food or water and leads to abdominal pain, anorexia and diarrhoea, which may resolve spontaneously in immunocompetent individuals but may persist in a chronic form in immunocompromised subjects, leading to a decline in their general state of health.	Preferred (foundation metadata concept)
A parasitic disease characterised by infestation of the skin with larvae of a variety of fly species. Furuncular myiasis specifically involves flies whose eggs are able to breach healthy skin, which concerns three species: Cordylobia anthropophaga (also called the African tumbu fly or Cayor worm for the larvae) and Cordylobia rodhaini (the Lund's fly), and Dermatobia hominis (the human botfly).	Preferred (foundation metadata concept)
A paroxysmal dystonic movement disorder occurring in association with gastro-oesophageal reflux, and, in some cases, hiatal hernia. The prevalence is unknown. Onset usually occurs during infancy or early childhood. The dystonic movements are characterised by abnormal posturing of the head and neck (torticollis) and severe arching of the spine. The dystonic movements are clearly associated with gastro-oesophageal reflux but the pathophysiological mechanism is not clearly understood.	Preferred (foundation metadata concept)
A part of the coeliac ganglion that is semidetached and contains sympathetic neurons that innervate the kidney.	Preferred (foundation metadata concept)
A partial autosomal monosomy characterised by variable combination of developmental delay, intellectual disability, ectodermal, genitourinary and minor cardiac anomalies, and specific dysmorphic features (prominent forehead and low-set ears). Specific combination depends on the size and breakpoints of deleted regions.	Preferred (foundation metadata concept)
A partial autosomal monosomy characterised clinically by lethal pulmonary disease that presents as severe respiratory distress and refractory pulmonary hypertension within a few hours after birth and typically results in death from respiratory failure within the first months of life. Characteristic histological features of lung tissue include paucity of alveolar wall capillaries, alveolar wall thickening, muscular hypertrophy of the pulmonary arteries, and malposition of the small pulmonary veins. Various additional congenital malformations may be associated, mostly gastrointestinal (intestinal malrotation and atresias, anular pancreas), genitourinary (dilatation of urinary tracts, duplicated uterus) and cardiovascular anomalies (hypoplastic left heart and other congenital heart defects).	Preferred (foundation metadata concept)
A partial deletion of the long arm of chromosome 17 characterised by hypotonia, growth delay, severe global developmental delay, microcephaly, seizures, congenital heart anomalies, hand and foot anomalies (syndactyly, symphalangism) and dysmorphic facial features, including round face, hypertelorism, upslanting palpebral fissures, and micrognathia. Reported deletions involve regions 17q21-q24.	Preferred (foundation metadata concept)
A partial deletion of the long arm of chromosome 4 characterised by complex behavioural difficulties, developmental and delay/ intellectual disability, and minor dysmorphic features, including subtle facial asymmetry (most prominent in the mandible), mild hypotelorism, long nasal bridge, small low-set ears, narrow mouth, and mild hand deformities, such as bilateral short 5th metacarpals, and short hands.	Preferred (foundation metadata concept)
A partial deletion of the short arm of chromosome 16 characterised by developmental delay, intellectual disability, speech delay, autism spectrum disorder, epilepsy, hypogonadism, and hypotonia. The behavioural profile includes impulsivity, compulsivity, stubbornness, manipulative behaviours, temper tantrums, and aggressive behaviours.	Preferred (foundation metadata concept)
A partial monosomy of the long arm of chromosome 9 characterised by intellectual disability, developmental delay with pronounced speech delay, short stature, and muscular hypotonia. Common craniofacial dysmorphic features consist of microcephaly, prominent forehead, round face, arched eyebrows, upslanting palpebral fissures, strabismus, short nose, and thin upper lip. Other clinical findings include epilepsy, ataxia, unspecific brain MRI findings, early-onset primary dystonia, nail dysplasia, and bone malformations, in particular patellar abnormalities, epistaxis, and cutaneous-mucous telangiectasias.	Preferred (foundation metadata concept)
A partial-thickness cornea transplant procedure that involves selective transplantation of the corneal stroma, preserving the Descemet membrane and endothelium.	Preferred (foundation metadata concept)
A pathological immune process generally directed towards a foreign antigen, which results in tissue injury, which is usually transient. It is the realization of the allergic disposition. It is most often applied to type I hypersensitivity but other hypersensitivity types especially type IV (e.g. allergic contact dermatitis) may be involved.	Preferred (foundation metadata concept)
A pathological impulse to write obscene letters or sexual arousal from writing obscenities.	Preferred (foundation metadata concept)
A pathological nonimmune process generally directed towards a foreign substance, which results in tissue injury, which is usually transient. It is the realization of the pseudoallergic disposition. A variety of mechanisms such as direct histamine release, complement activation, cyclooxygenase activation and bradykinin generation may be involved.	Preferred (foundation metadata concept)
A pathological process consisting of the formation of new blood vessels in the choroid.	Preferred (foundation metadata concept)
A pathological process initiated by exposure to a defined stimulus at a dose tolerated by normal persons. It may be the manifestation of a disposition to hypersensitivity.	Preferred (foundation metadata concept)
A patient encounter completed using an electronic text-based software application (ie. text-based chatting) that allows for asynchronous communication between the patient and a clinician or health care administrator.	Preferred (foundation metadata concept)
A patient speculated to have Ebola virus disease (EVD) based on symptomatology and history of exposure to the Ebola virus	Preferred (foundation metadata concept)
A patient under general anaesthesia with muscle relaxation who cannot be intubated by direct laryngoscopy and in whom mask ventilation is difficult and impossible.	Preferred (foundation metadata concept)
A patient without symptomatology or history to suggest concern for EVD.	Preferred (foundation metadata concept)
A pattern of caffeine use that has caused clinically significant harm to a person's physical or mental health or in which caffeine-induced behaviour has caused clinically significant harm to the health of other people. The pattern of caffeine use is evident over a period of at least 12 months if use is episodic and at least one month if use is continuous (daily or almost daily). Harm may be caused by the intoxicating effects of caffeine, the direct or secondary toxic effects on body organs and systems, or a harmful route of administration.	Preferred (foundation metadata concept)
A pattern of diamorphine use that leads to damage to an individual's physical or mental health or results in behaviour leading to physical or psychological harm to others. The pattern of use is observed for a minimum of 12 months for occasional use or at least one month for continuous use (daily or nearly daily). Health damage results from intoxication behaviours, direct or secondary toxic effects on body organs and systems, or harmful method of substance intake. Harm to others encompasses any physical or mental harm directly attributable to the user's intoxicated behaviour.	Preferred (foundation metadata concept)
A pattern of digital or video gaming behaviour that increases the risk of harmful physical or mental health outcomes for the individual or others. Harm has not yet occurred, but the gaming behaviour substantially elevates the likelihood of adverse consequences. This includes both online and offline gaming and does not meet the diagnostic threshold for a gaming disorder.	Preferred (foundation metadata concept)
A pattern of intravenous diamorphine use that leads to damage to an individual's physical or mental health or results in behaviour leading to physical or psychological harm to others. The pattern of use is observed for a minimum of 12 months for occasional use or at least one month for continuous use (daily or nearly daily). Health damage results from intoxication behaviours, direct or secondary toxic effects on body organs or systems or harmful method of substance intake. Harm to others encompasses any physical or mental harm directly attributable to the user's intoxicated behaviour.	Preferred (foundation metadata concept)
A pattern of nicotine use that has caused damage to a person's physical or mental health. The pattern of nicotine use is observed for a minimum of 12 months for occasional use or at least one month for continuous use (daily or nearly daily). Harm to health results from direct or secondary toxic effects on body organs and systems or a harmful route of administration.	Preferred (foundation metadata concept)

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Reference Sets

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Id	Description	Lang	Type	Status	Case?	Module
900000000001112010	Great Britain English language reference set	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT model component module (core metadata concept)
900000000001113017	GB English	en	Synonym (core metadata concept)	Active	Entire term case sensitive (core metadata concept)	SNOMED CT model component module (core metadata concept)
900000000001114011	Great Britain English language reference set (foundation metadata concept)	en	Fully specified name	Active	Entire term case sensitive (core metadata concept)	SNOMED CT model component module (core metadata concept)